Formulation evalution of atenolol hcl

Microemulsions usually exhibit low viscosities and Newtonian flow characteristics. A tablet was weighed before placing onto the tissue paper in the petri dish and time taken by tablet for complete wetting was noted.

The mucous secreted by the mucosa lining of stomach wall may detach the dosage form from the wall of the stomach which get emptied from the stomach along with its contents. If enough surfactant molecules are present, they align and create an interface between the water and the oil by decreasing the interfacial tension [8].

Pharma Boil World ;3: This indicates that the drug was compatible with the formulation components. Indeed, this is generally not the case. No experimental study has been conducted with microemulsions prepared by autoemulsification. Kinetic studies To analyze the release mechanism, several release models were tested such as: Then amount of the drug present in sample was calculated.

The balance was kept in this position for 3 min contact time. The results were shown in Table. The hardness of the tablets was found to be 5. Beta blockers may mask tachycardia occurring with hypoglycemia, but other manifestations such as dizziness and sweating may not be significantly affected.

Additionally, specialized dosage forms such as parenteral type ophthalmic solutions for intraocular, subtenons, and retrobulbar use; suspensions for insoluble substances such as hydrocortisone; and solids for reconstitution such as ecothiophate iodide and tetracycline, all present the drug product designer with composition and manufacturing procedure challenges in the development of pharmaceuticals.

The flexible interfacial film results in droplet sizes that fall in a range of nm in diameter for microemulsion systems. Verneir caliper was used to determine tablet thickness. The prepared tablets were evaluated for physical characteristics, bioadhesive strength, buoyancy lag time, swelling index and in vitro drug release studies.

The friability test was performed to assess the effect of friction and shocks, which may often cause the tablet to chip, cap or break. Characterizing the systems in this way results in three types of microemulsions: Wetting time within groups was highly significant, which indicates that wetting of tablets greatly affected by the concentration of superdisintegrants.

Formulation & Evalution of Atenolol Hcl Microemulsion for Ocular Administration

At recommended doses atenolol does not potentiate insulin-induced hypoglycemia and, unlike nonselective beta blockers, does not delay recovery of blood glucose to normal levels.

In this case, both water and oil exist as a continuous phase. The second factor is the drainage of the administered drop via the nasolacrimal system into the gastrointestinal tract which begins immediately upon instillation.

Over time, they will begin to separate back into their two phases. While taking beta blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic.

Effect of process and formulation variables on encapsulation efficiency, particle size, and in vitro dissolution rate. The second step consists of using a high pressure homogenizer. At the end of specified time intervals tablets were withdrawn from petri dish and excess buffer blotted with tissue paper and weighed.Formulation and evaluation of buccoadhesive tablets of Atenolol Prasad B Kadam* 1, Remeth J Dias 1, Kailas K Mali 1, Vijay D Havaldar 1 and Niranjan S Mahajan 1.

In all the formulations, the amount of atenolol was kept constant at 50 mg. The polymers like Carbopol p, HPMC K4M, HPMC K15M, and HPMC KM were used in different concentrations in combination. Total weight of the tablet was kept constant at mg.

formulation and evaluation of gastro retentive matrix tablets of atenolol using melt granulation technique Sarada Anepu *1, Lohithasu Duppala 2, Nikhil J.

3 and Janaki Devi S. 1 A.U. College of Pharmaceutical Sciences 1, Andhra University, Visakhapatnam, Andhra Pradesh, India. Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol park9690.comarathi, park9690.com*, park9690.comuthu Kumar, park9690.comlan.

In all the formulations, the amount of atenolol was kept constant at 50 mg. The polymers like Carbopol p, HPMC K4M, HPMC K15M, and HPMC KM were used in different concentrations in combination. Total weight of the tablet was kept constant at mg.

The formulae of different floating bioadhesive tablets of atenolol are given in Table 1. / Formulation and Evaluation of Atenolol Floating Tablets Using Different Polymers: Guargum, Sodium Alginate, Hpmccps and CarbopolHpmccps and Carbopol withN HCl.

Further 1ml of the above solution was diluted to 10 ml with N HCl and absorbance of the resulting solution was observed at nm.

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Formulation evalution of atenolol hcl
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